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Russ College of Engineering and Technology
Stocker Center
Athens, OH 45701

Stephen Bergmeier

Stephen Bergmeier
Professor, Chemistry and Biochemistry
Clippinger Hall 277
Biomedical Engineering
bergmeis@ohio.edu
740.597.9649
/chemistry/faculty/bergmeier.php

Research Interests: Drug Design, Drug Synthesis, Pharmaceutical Engineering

All Degrees Earned: Ph.D., Medicinal Chemistry, University of Michigan, 1990.

Journal Article, Academic Journal (39)

  • McCall, K., Walter, D., Patton, A., Thuma, J., Courreges de Benencia, M., Palczewski, G., Goetz, D., Bergmeier, S., Schwartz, F. (2023). Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD. 16. Journal of Inflammation Research; 2023: 5339-5366.
  • Ghazanfari, D., Courreges de Benencia, M., Belinski, L., Lloyd, J., Bergmeier, S., McCall, K., Goetz, D. (2022). Mechanistic Insights into SARS-CoV-2 Spike Protein Induction of the Chemokine CXCL10. Submitted.
  • Ghazanfari, D., Courreges, M., Belinski, L., Bergmeier, S., McCall, K., Goetz, D. (2022). Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19. Biochemical and Biophysical Research Communications; 605: 171-176.
  • Shriwas, P., Roberts, D., Li, Y., Wang, L., Qian, Y., Bergmeier, S., Hines, J., Adhicary, S., Nielsen, C., Chen, X. (2021). A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism. 14. Cancer Metab; 9.
  • Ghazanfari, D., Noori, M., Bergmeier, S., Hines, J., McCall, K., Goetz, D. (2021). A novel GSK-3 inhibitor binds to GSK-3尾 via a reversible, time and Cys-199-dependent mechanism.. Bioorganic & medicinal chemistry; 40: 116179.
  • Armstrong, I., Aldhumani, A., Schopis, J., Fang, F., Parsons, E., Zeng, C., Hossain, M., Bergmeier, S., Hines, J. (2020). RNA drug discovery: Conformational restriction enhances specific modulation of the T-box riboswitch function. 20. Bioorganic and Medicinal Chemistry; 28: 7. .
  • Noori, M., Courreges, M., Bergmeier, S., McCall, K., Goetz, D. (2020). Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.. European Journal of Pharmacology; 883: 173340.
  • Roberts, D., Wang, L., Zhang, W., Liu, Y., Shriwas, P., Qian, Y., Chen, X., Bergmeier, S. (2020). Isosteres of ester derived glucose uptake inhibitors.. 18. Bioorganic & medicinal chemistry letters; 30: 127406.
  • Noori, M., Bhatt, P., Courreges, M., Ghazanfari, D., Cuckler, C., Orac, C., McMills, M., Schwartz, F., Deosarkar, S., Bergmeier, S., McCall, K., Goetz, D. (2019). Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. Am J Physiol - Cell Physiol; 317: C1289-C1303.
  • Bergmeier, S., Zheng, Z. (2019). Routes to N-glycinamide oxazolidinone derivatives: The reaction of 4-trityloxymethyl-3- oxa-1-azabicyclo[3.1.0]hexan-2-one with active halides.. 3. Arkivoc; 1-13.
  • Bergmeier, S., Armstrong, I. (2017). Development of a Method for the Synthesis of 4-Aryl-Functionalized 2-Azabicyclo[3.2.1]octanes. 12. Synthesis; 49: 2733-2742. .
  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137. .
  • Fang, F., Maciagiewicz, I., Bergmeier, S. (2016). A synthesis of hexahydro H-oxazolo[3,4-a]pyrazin-3-ones from fused aziridines. 1. Heterocycles; 93.
  • Zeng, C., Zhou, S., Bergmeier, S., Hines, J. (2015). Factors that influence T box riboswitch efficacy and tRNA affinity. Bioorganic & Medicinal Chemistry; 23: 5702-5708.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-伪-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
  • Malki, A., Laha, R., Bergmeier, S. (2014). Synthesis and cytotoxic activity of MOM-ether analogs of isosteviol. Elsevier; 24: 1184-1187.
  • Zhou, S., Means, J., Acquaah-Harrison, G., Bergmeier, S., Hines, J. (2012). 1. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA . Bioorganic and Medicinal Chemistry; 20: 1298-1302.
  • Fang, F., Roberts, D., Zhou, S., Hines, J., Bergmeier, S. (2012). 2. A synthesis of 1,4-disubstituted Imidazolidin-2-ones from fused-ring aziridines I.W. Maciagiewicz. Synthesis; 44: 551-560.
  • Fang, F., Vogel, M., Hines, J., Bergmeier, S. (2012). 3. Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles . Org. Biomol. Chemistry; 10: 3080-3091.
  • Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qin, Y., Akbar, H., Colvin, R., Ding, J., Tong, L., Wu, S., Hines, J., Chen, X. (2012). 4. A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo . Mol. Cancer Ther; 11: 1672-1682.
  • Bergmeier, S., Wells, G., Huang, J., Katz, S. (2012). Studies on the ring opening reactions of 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones. Synthesis of aminomethyl oxazolidinones and aziridinyl ureas. Tetrahedron; 68: 3980-39887.
  • Bergmeier, S. (2012). 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human 伪4尾2 neuronal nicotinic acetylcholine receptors. Bioorganic and Medicinal Chemistry Letters; 22: 1797-1813.
  • Bergmeier, S., Huang, J. (2012). An improved synthesis of functionalized cis-dicahydroquinolines using a Baylis- Hillman-type adduct. Heterocycles; 84: 1289-1299.
  • Hurst, W., Krake, S., Bergmeier, S., Payne, M., Miller, K., Stuart, D. (2011). Impact of fermentation, drying, roasting and Dutch processing on flavan-3-ol stereochemistry in cacao beans and cocoa ingredients. . Chemistry Central Journal; 5.
  • Bergmeier, S., McMills, M. (2011). Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library. . Combinatorial Chemistry and High-Througput Synthesis; 15: 81-89.
  • Sumskaya, Y., Swain, P., Bergmeier, S., McMills, M., Priestley, N., Wright, D. (2011). Natural feedstocks for diversity-oriented synthesis: macrolide-like scaffolds from nonactate. Arkivoc; 144-166. ://WOS:000290685400013">http://://WOS:000290685400013.
  • Zhou, S., Acquaah-Harrison, G., Bergmeier, S., Hines, J. (2011). Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles. . Bioorganic and Medicinal Chemistry; 21: 7059-7063.
  • Orac, C., Zhou, S., Means, J., Boehm, D., Bergmeier, S., Hines, J. (2011). Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. 6786-6795. Journal of Medicinal Chemistry; 54.
  • Henderson, B., Orac, C., Maciagiewicz, I., Bergmeier, S., McKay, D. (2011). 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human 伪4尾2 neuronal nicotinic acetylcholine receptors. . Bioorganic and Medicinal Chemistry Letters; 21: 1797-1813.
  • Maciagiewicz, I., Zhou, S., Bergmeier, S., Hines, J. (2011). Structure activity studies of RNA-binding oxazolidinone derivatives. . Bioorganic and Medicinal Chemistry Letters; 21: 4524-4527.
  • Phillips, J., Smith, A., Kusche, B., Bessette, B., Swain, P., Bergmeier, S., McMills, M., Wright, D., Priestley, N. (2010). Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. 19. Bioorganic & Medicinal Chemistry Letters; 20: 5936-5938. ://WOS:000281735600073">http://://WOS:000281735600073.
  • Bergmeier, S., Liu, Y., Cao, Y., Zhang, W., Chen, X. (2010). Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms. . Cancer Lett.; 298: 176-185.
  • Bergmeier, S., Krake, S. (2010). Inter- and intramolecular reactions of epoxides and aziridines with pi-nucleophiles. . 37. Tetrahedron; 66: 7337-7360.
  • Bergmeier, S., Hines, J., Zhou, S., Acquaah-Harrison, G. (2010). A library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents. . 4. J. Comb. Chem.; 12: 491-496.
  • Bergmeier, S., Orac, C. (2010). Negative Allosteric Modulators that Target Human 伪4尾2 Neuronal Nicotinic Receptors. . J. Pharmaco. Exp. Ther.; 334: 761-774.
  • Bergmeier, S., Zhang, W., Chen, X., Liu, Y. (2010). Novel inhibitors of basal glucose transport as potential anticancer agents. Bioorg Med Chem Lett.; 20: 2191-2194.
  • Luesse, S., Wells, G., Nayek, A., Smith, A., Kusche, B., Bergmeier, S., McMills, M., Priestley, N., Wright, D. (2008). Natural products in parallel synthesis: Triazole libraries of nonactic acid. 14. Bioorganic & Medicinal Chemistry Letters; 18: 3946-3949. ://WOS:000257640400025">http://://WOS:000257640400025.
  • Nikodinovic, J., Dinges, J., Bergmeier, S., McMills, M., Wright, D., Priestley, N. (2006). Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions. 3. Organic Letters; 8: 443-445. ://WOS:000235120700023">http://://WOS:000235120700023.

Journal Article, Professional Journal (1)

  • McMills, M., Bergmeier, S. (2010). Natural Prtoduct Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis. 19. Bioorganic and Medicinal Chemistry Letters/Elsevier; 20: 5936-5938.

Patent (10)

  • Goetz, D., Begmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling . 10,633,377.
  • Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling -B. 10,407,420.
  • Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling - C . Application # 20200017489.
  • McMills, M., Goetz, D., Bergmeier, S., Orac, C. Imidazole and Thiazole Compositions for Modifying Biological Signaling . 10,023,567.
  • Bergmeier, S., Chen, X. Compositions and methods for glucose transport inhibition. US 10,000,443, B2.
  • Bergmeier, S., Chen, X. Compositions and Methods for Glucose Transport Inhibition. US Patent 9181162.
  • Goetz, D., McCall, K., Bergmeier, S., Schwartz, F., Bhatt, P., Deosarkar, S. Methods and compositions to modify GSK-3 activity.
  • Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
  • Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
  • Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.

Book, Chapter in Scholarly Book (3)

  • Bergmeier, S. (2013). Three-membered ring systems. Elsevier; 25: 47-70.
  • Bergmeier, S. (2011). Three-membered ring systems. Progress in Heterocyclic Chemistry; 23: 75-100.
  • Bergmeier, S., Lapinsky, D. (2010). Three-membered ring systems. . Progress in Heterocyclic Chemistry; 22: 59-83.