Nathan Weyand
Education
Ph.D., University of Utah
Research Interests
- Lab: Life Science Building 240
Many bacteria can persist in the body without eliciting disease symptoms. One bacterial pathogen capable of high levels of asymptomatic carriage in humans is Neisseria gonorrhoeae. N. gonorrhoeae recruits human proteins on the surface of infected cells to the site bacterial adhesion. I am working to understand the functional consequences of protein recruitment. For example, do recruited proteins protect N. gonorrhoeae from innate immune defenses like the complement cascade that can bind and kill this important human pathogen. A second area of my research is the development of animal models that mimic aspects of Neisseria-host interactions that have been refractory to in vivo experimentation including colonization, transmission and the spread of antimicrobial resistance.
Representative Publications
- Weyand NJ, Wertheimer AM, Hobbs TR, Sisko JL, Taku NA, Gregston LD, Clary S, Higashi DL, Biais N, Brown LM, Planer SL, Legasse AW, Axthelm MK, Wong SW, So M. (2013) . Proc Natl Acad Sci U S A 110(8): 3059-3064.
- Higashi DL, Biais, N, Weyand NJ, Agellon A, Sisko JL, Brown LM, So M. (2011) . PLoS One. 6(6): e21373.
- Weyand NJ, Calton CM, Higashi DL, Kanack KJ, So M. (2010) . Journal of Immunology. 184:694-701.
- Marri PR, Paniscus M, Weyand NJ, Rend贸n MA, Calton CM, Hern谩ndez DR, Higashi DL, Sodergren E, Weinstock GM, Rounsley SD, So M. (2010) . PLoS One. Jul 28;5(7):e11835.
- Weyand NJ, Lee SW, Higashi DL, Cawley D, Yoshihara P, So M. (2006) . Infection and Immunity 74: 2428-35.
Courses Taught
- BIOS 3210: General Microbiology
- BIOS 4270: Mechanisms of Gene Regulation